Chemical Biology

UC Berkeley and Gladstone scientists develop new Covid-19 test

December 7, 2020

image for lighting up covid test

In the diagnostic test, a patient sample is mixed with CRISPR Cas13 proteins (purple) and molecular probes (green) which fluoresce, or light up, when cut. When coronavirus RNA is present in the sample, it prompts the CRISPR proteins to snip the molecular probes, causing the whole sample to emit light. This fluorescence can be detected with a...

Catalyst breaks only molecules’ toughest C–H bonds

May 19, 2020

smokestacks

In new research reported in Nature, an international team of chemical engineers have designed a material that can capture carbon dioxide from wet flue gasses better than current commercial materials. One way to ameliorate the polluting impact of flue gases is to take the CO2 out of them and store it in geological formations or recycle it; there is, in fact, an enormous amount of research trying to find novel materials that can capture CO2 from these flue gasses.

The power of change in science

March 9, 2020

women trailblazers

Guided by CRISPR pioneer Jennifer Doudna, a formidable entrepreneur in her own right, C&EN profiled 15 women working in the Chemical industry in academics and startups in C&EN's 2020 Trailblazers. Four of them are affiliated with UC Berkeley's College of Chemistry. They have collectively launched more than 30 start-ups aimed at developing treatments for rare diseases, building better batteries, and more. They’re chemical scientists at the top of their game. They’re role models building and mentoring teams. And yes, they’re badasses. They live by the motto “Nobody ever got anywhere by listening to no.”

Meet our faculty: John Hartwig

November 15, 2019

John Hartwig

John Hartwig is the Henry Rapoport Professor of Chemistry at the University of California, Berkeley. He received the 2019 Wolf Prize in Chemistry. His research aims to find new metal-catalysed reactions, and he was one of the developers of the Buchwald-Hartwig amination, one of the most-used reactions in drug discovery. He spoke with Katrina Krämer at the 2019 American Chemical Society national meeting in Orlando, Florida.

Introducing our new faculty members and their lab groups

September 3, 2019

Shekar, Schepartz and Zuerch

This year, there will be three new lab groups forming under three new professors. Alanna Schepartz and Michael Zuerch are joining the Department of Chemistry; Karthik Shekhar will be in the Department of Chemical and Biomolecular Engineering. In the fall, new professors are often still in the process of moving in and awaiting new lab space setups.

Newly granted CRISPR patents boost UC’s U.S. portfolio to 10

August 2, 2019

The bacterial enzyme Cas9 is the engine of RNA-programmed genome engineering in human cells. (UC Berkeley graphic by K. C. Roeyer)

The University of California has received two new patents for use of the revolutionary CRISPR-Cas9 technology, increasing its gene-editing patent portfolio to 10. Five more are expected to be issued by the U.S. Patent and Trademark Office by the end of the summer.

The patents were awarded today to UC and its co-patentees, the University of Vienna and Emmanuelle Charpentier, who co-invented CRISPR-Cas9 with UC Berkeley's Jennifer Doudna.

Department of Chemistry welcomes new faculty

May 10, 2019

Alanna Schepartz and Michael Zuerch join the department of chemistry

Matthew Francis, Chair of the Department of Chemistry at UC Berkeley, announces the addition of two new faculty members who will join the College in July. Alanna Schepartz joins the faculty as the T. Z. and Irmgard Chu Distinguished Chair in Chemistry; Michael Zuerch joins the faculty as an Assistant Professor of Physical Chemistry.

John Hartwig: The 2019 Wolf Prize and the importance of fundamental research in the discovery of synthetic catalysts

March 9, 2019

John Hartwig In a press release issued in January by the Wolf Foundation in Israel, it was announced that Professors John Hartwig and Stephen Buchwald (MIT) had been jointly awarded the 2019 Wolf Prize in Chemistry for independently harnessing cross coupling for the making of carbon-heteroatom bonds. The Foundation noted, “These bonds and especially the carbon-nitrogen bonds are immensely important, because such bonds constitute a very basis of medicinal chemistry."

Alumni innovation in the news

March 13, 2019

Ripple MilkGraduates of the College’s Chemistry and Chemical and Biomolecular Engineering departments are making news as they become market innovators with their recent startups and products. News stories about Lygos, Chemistry and Ripple look at the latest chemistry innovations and funding for these companies.

Discovery of a pathway for terminal-alkyne amino acid biosynthesis

March 15, 2019

Michelle ChangUC Berkeley researchers, led by Professor of Chemistry Michelle Chang, have discovered a biosynthetic pathway that makes amino acids containing terminal alkynes. Because such functional groups are rare in natural products, they provide a handle for chemistry that’s not generally found in biological organisms. For example, chemists could use such groups to attach fluorescent dyes to proteins via click chemistry.