CRISPR

CRISPR Cas9 explained. CRISPR (clustered regularly interspaced short palindromic repeats) are segments of prokaryotic DNA containing short repetitions of base sequences. is an RNA-guided gene-editing platform that makes use of a bacterially derived protein (Cas9) and a synthetic guide RNA to introduce a double strand break at a specific location within the genome.

Cas9 is an enzyme that snips DNA, and CRISPR is a collection of DNA sequences that tells Cas9 exactly where to snip.

Meet scientist Markita Landry

February 13, 2019

Markita LandryIn this engaging article, meet Markita Landry, Assistant Professor of Chemical and Biomolecular Engineering, who runs the Landry Lab at UC Berkeley. Her lab works on developing nanomaterials to assist in the delivery of CRISPR-Cas9 systems in plants.

Scientists find new and smaller CRISPR gene editor: CasX

February 5, 2019

new gene-editing protein CasX announcedAccording to a newly published study in Nature, CasX is a potent and efficient gene editor in both bacteria and human cells. Its design is similar to Cas9 and its well-studied cousin, Cas12, but is different enough that it appears to have evolved in bacteria independently of the other Cas proteins. It can cut double-stranded DNA like Cas9, can bind to DNA to regulate genes, and it can be targeted to specific DNA sequences like other Cas proteins.

Freakonomics Radio interviews Jennifer Doudna: Evolution, Accelerated

June 14, 2017

Freakanomics RadioA breakthrough in genetic technology has given humans more power than ever to change nature. It could help eliminate hunger and disease; it could also lead to the sort of dystopia we used to only read about in sci-fi novels. So what happens next?

‘The Joy of the Discovery’: An Interview with Jennifer Doudna

January 24, 2019

Jennifer DoudnaJennifer Doudna was awarded the Pearl Meister Greengard Prize in October 2018, established by Nobel Laureate Paul Greengard and his wife, the artist Ursula von Rydingsvard, to give recognition to women scientists. The New York Review spoke with her before the award ceremony. “That there even is a prize like this one,” Doudna said, “is a sign that people are really beginning to value the contributions of women to science.”

Genome-editing revolution: My whirlwind year with CRISPR

December 22, 2015

Jennifer DoudnaJennifer Doudna, a pioneer of the revolutionary genome-editing technology, reflects on how 2015 became the most intense year of her career — and what she's learned.

Read the article.

UC vows to protect groundbreaking CRISPR invention despite court decision

September 11, 2018

DNA photo - Getty Images

A statement about the U.S. Court of Appeals decision on the University of California's patent interference claim before the Patent Trial and Appeal Board b by Charles F. Robinson, Office of General Counsel, UC Office of the President.

Mammoth Biosciences Raises $23M in Series A Round

July 31, 2018

Jennifer Doudna. Photo by Washington Post, Getty Images.Mammoth Biosciences, the biotech startup cofounded by CRISPR researcher Jennifer Doudna, announced today that it has raised $23 million in a Series A round of financing.

Patent awarded for DNA-targeting complex at heart of CRISPR-Cas9 gene editing

October 30, 2018

CRISPR-CAS9 patent awarded to UC Berkeley and Jennifer DoudnaThe University of California announced today that the U.S. Patent and Trademark Office has granted U.S. Patent Number 10,113,167, covering unique RNA guides that, when combined with the Cas9 protein, are effective at homing in on and editing genes. These RNA/protein combinations act like precision-targeted gene-editing scissors.