CRISPR

CRISPR Cas9 explained. CRISPR (clustered regularly interspaced short palindromic repeats) are segments of prokaryotic DNA containing short repetitions of base sequences. is an RNA-guided gene-editing platform that makes use of a bacterially derived protein (Cas9) and a synthetic guide RNA to introduce a double strand break at a specific location within the genome.

Cas9 is an enzyme that snips DNA, and CRISPR is a collection of DNA sequences that tells Cas9 exactly where to snip.

Patent awarded for DNA-targeting complex at heart of CRISPR-Cas9 gene editing

October 30, 2018

CRISPR-CAS9 patent awarded to UC Berkeley and Jennifer DoudnaThe University of California announced today that the U.S. Patent and Trademark Office has granted U.S. Patent Number 10,113,167, covering unique RNA guides that, when combined with the Cas9 protein, are effective at homing in on and editing genes. These RNA/protein combinations act like precision-targeted gene-editing scissors.

CRISPR opens door to new type of medicine: ‘genome surgery’

October 25, 2018

Jennifer DoudnaIGI researchers, including Bruce Conklin of UCSF and Jennifer Doudna of UC Berkeley, discuss the promise of CRIRSP-Cas9 'genome surgery.'

Smallest life forms have smallest working CRISPR system

October 18, 2018

Archaea bacteria with CRISPR systems.

An ancient group of microbes that contains some of the smallest life forms on Earth also has the smallest CRISPR gene-editing machinery discovered to date.

Five distinguished individuals to be honored with highest American Cancer Society Award

October 17, 2018

American Cancer Society LogoThe American Cancer Society will bestow its highest honor – the Medal of Honor – to five individuals on Oct. 18 in Washington DC. The Medal of Honor is awarded to distinguished individuals who have made valuable contributions in the fight against cancer. The 2018 recipients include the Honorable Joseph R. Biden Jr., for Cancer Control; Emmanuelle Charpentier, PhD, for Basic Research; Jennifer Doudna, PhD, for Basic Research; Charis Eng, MD, PhD, for Clinical Research; and Michael J. Thun MD, MS, for Cancer Control Science.

Doudna joins Biden during Bay Area stop on cancer ‘listening tour’

February 29, 2016

Jennifer DoudnaWhen Vice President Joe Biden dropped by UC San Francisco on Saturday for a wide-ranging discussion of the current state of cancer research, UC Berkeley’s Jennifer Doudna was on hand to emphasize the need to fund basic research as well as clinical research.

New CRISPR inhibitors found with help from U.S. Defense Department funding

October 4, 2018

CRISPR/Cas12a system. Photo courtesy C&EN, Illusciences.

As scientists march closer to using CRISPR gene editing to treat diseases, the U.S. Department of Defense is prepping for the possibility of a more nefarious use of CRISPR: its weaponization to harm humans, animals, or crops.

Professor Jennifer Doudna speaks at UH Hilo about her CRISPR discovery

September 22, 2018

Jennifer Doudna gives lecture in Hilo, Hawaii.

Professor Jennifer Doudna ( seen here with (left) UH Hilo Interim Chancelor Marcia Sakai and (right) UH Hilo Chancelor Emerita Rose Tseng presented the inaugural UH Hilo Rose and Raymond Tseng Distinguished Lecture. view video here

Why the gene editors of tomorrow need to study ethics today

September 19, 2018

Jennifer Doudna and Jiwoo Lee. Photo courtesy of Michelle Groskopf, Wired Magazine

Two years after biochemist Jennifer Doudna helped introduce the world to the gene-editing tool known as Crispr, a 14-year-old from New Jersey turned it loose on a petri dish full of lung cancer cells, disrupting their ability to multiply.