Organic Chemistry

Holy grails: seeking out selective C–H activation

October 1, 2020

Demonstration of complexity of C-H targets

The sheer number of C–H bonds in the precursor to the antibiotic erythromycin shows just how tricky a task it is to target a single one. The oxidation of a single C–H bond (red) makes erythromycin six times more biologically active than its precursor 6-deoxy erythromycin A – this chemical feat...

Meet our faculty: Robert Bergman

December 10, 2019

Robert Bergman

On the first day of graduate school, I went to my physical organic chemistry class feeling nervous and intimidated. The class was taught by Bob Bergman, a chemist whose extensive scientific record and research contributions I had learned about as an undergraduate. Many professors who excel at research are, unfortunately, not good teachers, so I had no idea what to expect. In his first lecture, Bergman played a movie of his young granddaughter experimenting with a saltshaker, and he explained how excited children are about figuring out how things work.

What happens when your discovery becomes personal?

August 22, 2019

Richmond Sarpong

Until this year Robert Harris and Robert Bergman have been esteemed colleagues at the College. Recently however, when they were at an event discussing an interview Bergman had done with Professor William Lester, they made a very interesting personal discovery. Their lives had more than crossed as children living in Chicago’s Hyde Park. In fact, they had lived about 100 yards from each other across an alleyway.

John Hartwig: The 2019 Wolf Prize and the importance of fundamental research in the discovery of synthetic catalysts

March 9, 2019

John Hartwig In a press release issued in January by the Wolf Foundation in Israel, it was announced that Professors John Hartwig and Stephen Buchwald (MIT) had been jointly awarded the 2019 Wolf Prize in Chemistry for independently harnessing cross coupling for the making of carbon-heteroatom bonds. The Foundation noted, “These bonds and especially the carbon-nitrogen bonds are immensely important, because such bonds constitute a very basis of medicinal chemistry."

Chem alum struggled with learning disability to achieve genius

December 7, 2018

Richard HoughtenAt this year's induction ceremony for the Florida Inventors Hall of Fame, Torrey Pines Institute for Molecular Studies founder Richard Houghten and optometry pioneer Herbert Wertheim — two individuals of unquestionable genius — shared a surprising fact about themselves: Growing up, they each struggled with severe learning challenges that easily could have sent them on a different path.

Aduro Biotech creates new postdoc diversity fellowship at Berkeley

September 16, 2018

Jennifer DoudnaProfessor of Chemistry Richmond Sarpong, and Chairman, President and CEO of Aduro Biotech, Stephen Isaacs, discuss the Aduro-UC Berkeley Underrepresented Postdoctoral Fellowship Program which was launched in 2018. Sarpong is seen here with the first fellowship recipient Alex Rovira.