CRISPR

CRISPR Cas9 explained. CRISPR (clustered regularly interspaced short palindromic repeats) are segments of prokaryotic DNA containing short repetitions of base sequences. is an RNA-guided gene-editing platform that makes use of a bacterially derived protein (Cas9) and a synthetic guide RNA to introduce a double strand break at a specific location within the genome.

Cas9 is an enzyme that snips DNA, and CRISPR is a collection of DNA sequences that tells Cas9 exactly where to snip.

UC Berkeley Receives CRISPR Patent in Europe

March 24, 2017
by Jef Akst

Emmanuelle Charpentier, Jennifer Doudna receiving 2017 Japan PrizeThe European Patent Office will grant patent rights over the use of CRISPR in all cell types to a University of California team, contrasting with a recent decision in the U.S.

http://www.the-scientist.com/?articles.view%2FarticleNo%2F48987%2Ftitle%2FUC-Ber…

CRISPR pioneer Jennifer Doudna shines hope on the future of genetic modification at SXSW

March 11, 2017
by Megan Rose Dickey, Sarah Buhr

Jennifer Doudna, co-inventor of CRISPR Cas9 technology, or the ability to program genes using a special enzyme, spoke about the promises of this technology onstage at SXSW.

https://techcrunch.com/2017/03/11/crispr-pioneer-jennifer-doudna-shines-hope-on-…

Meet the Scientist Bringing Gene Editing to Life: An Interview With Jennifer Doudna

February 16, 2017
by Jessica Wapner

Jennifer DoudnaNewsweek spoke with Doudna about the CRISPR-Cas9 technology ruling and what’s next for her.

http://www.newsweek.com/jennifer-doudna-interview-gene-editing-557572

CRISPR’s breakthrough problem

February 13, 2017
by Ryan Cross

Graphic by Yang H Ku, C&ENIf the CRISPR gene editing system is to live up to its disease-curing potential, researchers must devise a plan to deliver it into the body.

http://cen.acs.org/articles/95/i7/CRISPRs-breakthrough-problem.html

Patent office determines UC, Broad Institute patent claims on CRISPR-Cas9 genome editing are separately patentable

February 15, 2017
By Public Affairs, UC Berkeley

Jennifer Doudna. Photo by Keegan Houser.The Patent Trial and Appeal Board (PTAB) of the U.S. Patent and Trademark Office (USPTO) today ruled that the inventions claimed in the pending U.S. patent application filed by the Doudna/Charpentier research group and the patents and applications filed by the Broad Institute are separately patentable from one another, thereby moving the...

http://news.berkeley.edu/2017/02/15/patent-office-determines-uc-broad-institute-…

CRISPR research institute expands into agriculture, microbiology

January 25, 2017
by Robert Sanders, UC Berkeley Media Relations

Reflection of trees in Strawberry Creek. Photo by Keegan Houser.An initiative launched two years ago by UC Berkeley and UC San Francisco to use CRISPR-Cas9 gene editing to develop new disease therapies is expanding into research on the planet’s major crops and poorly understood microbiomes, with plans to invest $125 million in these areas over the next five years.

http://news.berkeley.edu/2017/01/24/crispr-research-institute-expands-into-agric…

Compact CRISPR systems found in some of world’s smallest microbes

December 22, 2016
Robert Sanders, Media Relations

Jennifer DoudnaUC Berkeley scientists have discovered simple CRISPR systems similar to CRISPR-Cas9 — a gene-editing tool that has revolutionized biology — in previously unexplored bacteria that have eluded efforts to grow them in the laboratory.

http://news.berkeley.edu/2016/12/22/compact-crispr-systems-found-in-some-of-worl…

CRISPR toolbox expanded by protein that cuts RNA in two distinct ways

September 26, 2016
By Public Affairs, UC Berkeley

Jennifer DoudnaUC Berkeley biochemist Jennifer Doudna, molecular biologist Robert Tijan and a team of researchers have expanded the role of the newly discovered CRISPR protein C2c2 that targets RNA instead of DNA.

http://news.berkeley.edu/2016/09/26/crispr-toolbox-expanded-by-protein-that-cuts…

Doudna calls for human gene-editing moratorium

March 23, 2015
Nicholas Wade

Jennifer DoudnaWriting in Science magazine, Inventor of CRISPR technique urges effort to explore ethical issues.

Read the full article.

http://nyti.ms/19DfnrB

Faster, more efficient CRISPR editing in mice

May 27, 2016
by Robert Sanders, Berkeley Media Relations

DNA helixBerkeley scientists have developed a quicker and more efficient method to alter the genes of mice with CRISPR-Cas9. The work benefited from input from Professor Jennifer Doudna.

Read the article.

http://news.berkeley.edu/2016/05/27/faster-more-efficient-crispr-editing-in-mice…