CRISPR

CRISPR Cas9 explained. CRISPR (clustered regularly interspaced short palindromic repeats) are segments of prokaryotic DNA containing short repetitions of base sequences. is an RNA-guided gene-editing platform that makes use of a bacterially derived protein (Cas9) and a synthetic guide RNA to introduce a double strand break at a specific location within the genome.

Cas9 is an enzyme that snips DNA, and CRISPR is a collection of DNA sequences that tells Cas9 exactly where to snip.

Gene editing will transform cancer treatment

November 21, 2016
by Elizabeth Lopatto, Science Editor, The Verge

Jennifer DoudnaThe Verge talks with Jennifer Doudna to discuss just what CRISPR might mean for the future of science, and disease research.

http://www.theverge.com/a/verge-2021/jennifer-doudna-crispr-gene-editing-healthc…

Gene editing could stop cancer, diabetes and bioterrorism: An interview with CRISPR scientist Jennifer Doudna

August 5, 2017
By Jessica Firger

Jennifer Doudna. Still of video by Roxanne Makasdjian, Stephen McNally.

Newsweek spoke with Jennifer Doudna co-discover of the breakthrough gene-editing technique, about how quickly the technology is advancing and the progress she expects to see in the future.

http://www.newsweek.com/crispr-gene-editing-cancer-diabetes-bioterrorism-jennife…

White House summit advances the ‘cancer moonshot’

June 29, 2016
by UC Berkeley Public Affairs

Jennifer DoudnaThe cancer moonshot aims to end cancer as it is known today. One of the key discoveries in that effort is CRISPR/Cas9 pioneered by Jennifer Doudna.

Read the article.

http://news.berkeley.edu/2016/06/29/cancer-moonshot-summit-jump/

Doudna joins Biden in Davos rollout of ‘cancer moonshot’

January 19, 2016
by Robert Sanders

Doudna at World Economic ForumJennifer Doudna joined Joseph Biden this morning at the World Economic Forum in Davos, Switzerland, as the vice president promoted a major new U.S. initiative to speed the discovery of cures for cancer, what President Obama has dubbed a "cancer moonshot."...

http://news.berkeley.edu/2016/01/19/doudna-joins-biden-in-davos-rollout-of-cance…

Breakthrough of the Year: CRISPR makes the cut

December 17, 2015
by John Travis

Science singles out CRISPR gene-editing as the Breakthrough of the Year.

Read the article.

http://news.sciencemag.org/scientific-community/2015/12/and-science-s-breakthrou…

Taiwan’s Tang Prizes awarded to Doudna, Rosenfeld

June 20, 2016
by Robert Sanders

Jennifer DoudnaTaiwan's top science award, the Tang Prize, has gone to two UC Berkeley scientists well-known in the fields of biochemistry and physics: Jennifer Doudna, for her invention of CRISPR-Cas9 gene editing, and Arthur Rosenfeld, often called the "godfather of energy efficiency."

...

http://news.berkeley.edu/2016/06/20/taiwans-tang-prizes-awarded-to-doudna-rosenf…

CRISPR-Gold fixes Duchenne muscular dystrophy mutation in mice

October 3, 2017
By Brett Israel, Media relations

Scientists at the University of California, Berkeley, have engineered a new way to deliver CRISPR-Cas9 gene-editing technology inside cells and have demonstrated in mice that the technology can repair the mutation that causes Duchenne muscular dystrophy, a severe muscle-wasting disease.

http://news.berkeley.edu/2017/10/03/crispr-gold-fixes-duchenne-muscular-dystroph…

Discovery helps engineer more accurate Cas9s for CRISPR editing

September 20, 2017
By Robert Sanders, Media relations

Cas9 VectorsScientists at the University of California, Berkeley and Massachusetts General Hospital have identified a key region within the Cas9 protein that governs how accurately CRISPR-Cas9 homes in on a target DNA sequence, and have tweaked it to produce a hyper-accurate gene editor...

http://news.berkeley.edu/2017/09/20/discovery-helps-engineer-more-accurate-cas9s…

CRISPR: A Crack in Creation

August 28, 2017
The Aspen Ideas to Go Podcast

Jennifer Doudna at Aspen Ideas FestivalCRISPR is the cheapest, simplest, and most effective way of manipulating DNA. It has the power to give us the cure to HIV, genetic diseases, and some cancers. It could even help address the world's hunger crisis. But, it may result in unforeseen consequences. The technology could lead to intentionally mutating embryos to create "better" humans. Jennifer Doudna, whose research...

https://www.aspeninstitute.org/podcasts/crispr-crack-creation/

Doudna awarded NHGRI grant for CRISPR-based research

August 22, 2017
GenomeWeb

Jennifer DoudnaJennifer Doudna and Feng Zhang have received separate grants from the National Human Genome Research Institute for CRISPR technology-based projects they both say have the potential to advance the tool's usefulness for human health purposes.

The University of California, Berkeley's Doudna will receive $2.1 million to set up and run the Center for Genome Editing and Recording (CGER)....

https://www.genomeweb.com/research-funding/jennifer-doudna-feng-zhang-awarded-nh…