CRISPR

CRISPR Cas9 explained. CRISPR (clustered regularly interspaced short palindromic repeats) are segments of prokaryotic DNA containing short repetitions of base sequences. is an RNA-guided gene-editing platform that makes use of a bacterially derived protein (Cas9) and a synthetic guide RNA to introduce a double strand break at a specific location within the genome.

Cas9 is an enzyme that snips DNA, and CRISPR is a collection of DNA sequences that tells Cas9 exactly where to snip.

Brewing hoppy beer without the hops

March 20, 2018
by Robert Sanders, Berkeley Media Relations

Charles Denby and Rachel Li, UC Berkeley researchers.Berkeley researchers Charles Denby and Rachel Li, have created strains of yeast that produce a hoppy flavor in beer without the use of hops.

http://news.berkeley.edu/2018/03/20/brewing-hoppy-beer-without-the-hops/

CRISPR scissors, Cas12a, enables cutting-edge diagnostics

February 15, 2018

CRISPR-Cas12a TestingCRISPR-Cas12a, one of the DNA-cutting proteins revolutionizing biology today, has an unexpected side effect that makes it an ideal enzyme for simple, rapid and accurate disease diagnostics.

Berkeley News: ...

National Academy of Sciences honors Raghavendra, Doudna

January 17, 2018
by Robert Sanders, UC Berkeley Media Relations

Jennifer DoudnaPrasad Raghavendra, an associate professor of electrical engineering and computer science, and Jennifer Doudna, a professor of molecular and cell biology and of chemistry, were honored this week by the National Academy of Sciences for their innovative body of research.

http://news.berkeley.edu/story_jump/national-academy-of-sciences-honors-raghaven…

Chocolate is on track to go extinct in 40 years

December 31, 2017
Erin Brodwin

Student estimating amount of candy in beakerScientists at the University of California are teaming up with Mars company to try to save the crop before it's too late.

http://www.businessinsider.com/when-chocolate-extinct-2017-12

First step toward CRISPR cure of Lou Gehrig's disease

December 20, 2017
By Robert Sanders, Media relations

David SchafferDavid Schaffer and fellow UC Berkeley scientists have for the first time used CRISPR-Cas9 gene editing to disable a defective gene that causes amyotrophic lateral sclerosis, or Lou Gehrig's disease, in mice, extending their lifespan by 25 percent.

http://news.berkeley.edu/2017/12/20/first-step-toward-crispr-cure-of-lou-gehrigs…

Watch Real Moving Images of CRISPR/Cas9 Cutting DNA

November 21, 2017
By Dr. Barry Starr

movie of DNA search and cleavage by CRISPR-Cas9 by Osamu NurekiResearcher Osamu Nureki used high‐speed atomic‐force microscopy to film a tiny needle move back and forth across Cas9.

https://ww2.kqed.org/futureofyou/2017/11/21/watch-crisprcas9-in-action-in-this-r…

Life, gene editing, and rock ’n’ roll

November 15, 2017
By Tor Haugan

Jennifer DoudnaJennifer Doudna, professor and co-inventor of CRISPR-Cas9 gene editing, speaks with Susan Koskinen, head of the Life and Health Sciences Library Division, at the Bioscience & Natural Resources Library on Nov. 14, 2017.

http://news.lib.berkeley.edu/2017/11/15/doudna/

Book Club: A Crack in Creation

October 19, 2017
Chemistry World

A Crack in CreationPodcast on the development of Crispr, and the ethical questions raised by new genome editing techniques.

https://www.chemistryworld.com/podcasts/book-club-a-crack-in-creation/3008155.ar…

The CRISPR target-recognition mechanism

October 18, 2017
Contacts: Addison Wright and Junjie Liu

Cas1-Cas2 complexResearchers have discovered how Cas proteins are able to recognize their target locations with such great specificity.

https://als.lbl.gov/the-crispr-target-recognition-mechanism/

Doudna awarded Japan Prize for invention of CRISPR gene editing

February 2, 2017
Robert Sanders, Media Relations

Emmanuelle Charpentier, Jennifer Doudna receiving 2017 Japan PrizeJennifer Doudna and Emmanuelle Charpentier were awarded the Japan Prize today for their invention of the revolutionary gene-editing technology known as CRISPR-Cas9, which has swept into research labs around the world and is already yielding new therapies for cancer and hereditary diseases.

http://news.berkeley.edu/story_jump/doudna-awarded-japan-prize-for-invention-of-…