Donors to the College of Chemistry have generously established a total of twenty-five chairs and professorships. In chronological order, they are:
| Name of Chair | Established | Current Chairholder |
| The Joel Hildebrand Distinguished Professorship (to be occupied by the Chair of the Department of Chemistry) |
1981 | Daniel M. Neumark | |
| The Glenn T. Seaborg Chair in Physical Chemistry | 1998 | Alexander Pines | |
| The Kenneth S. Pitzer Distinguished Professorship in Chemistry | 1998 | Martin P. Head-Gordon | |
| The Gilbert Newton Lewis Endowed Chair (to be occupied by the Dean of the College of Chemistry) |
2001 | Richard A. Mathies | |
| The Henry Rapoport Chair in Organic Chemistry | 2001 | John F. Hartwig | |
| The Warren and Katharine Schlinger Distinguished Professorship in Chemical Engineering (to be occupied by the Chair of the Department of Chemical & Biomolecular Engineering) |
2002 | Douglas S. Clark | |
| The Hubbard Howe Jr. Distinguished Professorship in Biochemical Engineering | 2002 | Jay Keasling | |
| The Professor Gerald K. Branch Distinguished Professorship in Chemistry | 2002 | Robert G. Bergman | |
| The Aldo DeBenedictis Distinguished Professorship in Chemistry | 2002 | vacant | |
| The Melvin Calvin Distinguished Professorship in Chemical Biodynamics | 2003 | Graham R. Fleming | |
| The Chevron Chair in Chemistry | 2004 | Ming Hammond | |
| The John R. Thomas Endowed Chair in Physical Chemistry | 2004 | Stephen R. Leone | |
| The T. Z. and Irmgard Chu Distinguished Professorship in Chemistry | 2004 | Carolyn R. Bertozzi | |
| The Charles Wilke Endowed Chair in Chemical Engineering | 2004 | Danielle Tullman-Ercek | |
| The Bruce H. Mahan Chair in Physical Chemistry | 2005 | David Chandler | |
| The Larry and Diane Bock Endowed Chair in Nanotechnology | 2006 | A. Paul Alivisatos | |
| The Charles W. Tobias Chair in Electrochemistry | 2006 | vacant | |
| The Theodore Vermeulen Chair in Chemical Engineering | 2006 | Enrique Iglesia | |
| The Merck Chair in Biochemical Engineering | 2007 | Harvey W. Blanch | |
| The Cupola Era Endowed Chair in the College of Chemistry | 2008 | Thomas Maimone | |
| The James and Neeltje Tretter Endowed Chair in Chemistry | 2008 | Omar Yaghi | |
| The Dow Chair in Sustainable Chemistry | 2008 | Alexis T. Bell | |
| The Lieselotte and David Templeton Endowed Chair in Chemistry | 2010 | Kristie A. Boering | |
| The Lam Research Distinguished Chair in Semiconductor Processing | 2011 | David B. Graves | |
| The C. Judson King Endowed Chair in Chemical and Biomolecular Engineering | 2011 | Jeffrey A. Reimer |