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Chemistry News
by Charles Harris, Chair

Focus on Rapidly Growing Disciplines


s I begin my tenure as the chair of the chemistry department I find that the learning curve is steep and my time is stretched thinner than I ever thought possible. I have new appreciation for the job done by my predecessor, Judith Klinman. A large fraction of our chemical biology faculty and most of the current assistant professors were hired under her tutelage. We all owe her a vote of thanks!

In spite of the work load, it has been a rewarding few months as we begin the new semester and take stock of what current and future issues the department will face. I would like to use this column to talk to you about two areas of research, materials chemistry and chemical biology, both of which are growing rapidly in terms of the number of interested graduate students as well as in research funding and space.

The emergence of materials chemistry at Berkeley Chemistry as a subject is always evolving, and one area of rapid growth presently is at the interface between materials science and chemistry. Part of this growth arises naturally as chemists systematically develop the means to control the composition of artificial materials on ever longer length scales.

While it remains a challenge to control the precise arrangement of atoms within a molecule, or even of the subunits within a polymer, the fact is that todays chemists are learning to assemble much more complex components. For example, Matt Francis and his coworkers seek to harness the self-assembly of virus coat proteins into micron-size capsules. By modifying these proteins in select locations, Francis can use the self-assembling proteins to spatially arrange artificial atoms, namely nanocrystals, much as in the past his predecessors sought to control the spatial arrangement of atoms within molecules.

As the materials that chemists can make increase in complexity, the possibility that these materials can possess unique physical and chemical characteristics is greatly increased. Peidong Yang and his coworkers have learned how to make nanowires of many inorganic substances. Yang is working to develop one-dimensional superlattices, wires with alternating layers of materials on the nanometer scale, which may possess the proper combination of high electrical conductivity and low thermal conductivity for use on thermoelectric refrigeration.

Paul Alivisatos has a large wet lab dedicated to the synthesis of nanocrystals, sitting side by side with complex instrumentation for structural and compositional analysis, as well as home-made instruments for evaluation of complex materials, such as nanorod-polymer solar cells. Likewise the laboratories of Jean Fréchet bear little resemblance to those of an organic or polymer chemist of twenty years ago; they are now packed with diverse instrumentation that permits the investigation of novel dendrimeric and polymeric materials.

Materials chemistry is emerging as an important subdiscipline within our chemistry department, cutting across the traditional subjects of organic, inorganic, physical, and biological chemistry. Further, the subject matter of materials chemistry brings us into close and productive contact with our colleagues across the campus in chemical engineering, physics, materials science, and electrical, mechanical, and bio-engineering. In the coming years the department will be examining the needs of the faculty and students in this area, and how the right conditions can be established so that this subject area can thrive.

Nationally, a new Nanoscience Subdivision was just established in the Division of Inorganic Chemistry of the ACS to promote activities related to nanoscience research. As the chair of the division, Don Tilley initiated this change. Peidong Yang is chair of the new subdivision, and a symposium is being planned for the 2004 ACS meeting in Anaheim to kick off this new group.

Chemical Biology continues to grow
We are at the beginning of the third year of our Chemical Biology Graduate Program (CBGP). Ten students were admitted in the 2003 class bringing the total enrollment in the CBGP to 24. The opportunity to carry out three ten-week rotations in laboratories in the chemistry, chemical engineering and molecular and cell biology departments is an important factor to those that decide to join the program. The diversity of experimental experiences during the three rotations will no doubt serve to broaden the thesis work carried out by CBGP students.

The Bachelor of Science in Chemical Biology undergraduate major is off to a great start. Ken Sauer, working with members of the chemistry department, assembled a curriculum that maintains the rigor of our traditional B.S. in Chemistry, while making it possible to incorporate modern aspects of biology. Michael Marletta and Jamie Cate are teaching a central piece of the new curriculum, Chemistry 135, for the second time this fall. Fifty students are currently enrolled and most are chemistry majors.

Awards and Honors
Our faculty members continue to garner well-deserved accolades. Darleane Hoffman received Sigma Xi's 2003 William Procter Prize for Scientific Achievement; Carlos Bustamante received the Founders Award from the Biophysical Society; Don Tilley is the winner of the prestigious Wacker Silicone Award 2003; both Jay Groves and Peidong Yang were elected the TR100, a list of the top 100 innovative young scientists in the world, compiled by Technology Review magazine.


Related sites

Matt Francis

Peidong Yang

Paul Alivisatos

Jean Fréchet

Chemical Biology Graduate Program

   

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